BGS Global Institute of Medical Sciences

Research Institute Staff Details

Faculty of Research

NameAcademic QualificationDesignation
Dr. Chandru.HM.Sc., Ph.D., PDF (Canada)., RA (USA)  Director
Dr. Suman SamaddarM.Pharm., Ph.D.  Research Scientist-II
Ms. Lincy JoshuaM.Sc.  Lab  Manager
Mr. Sanjay K  M.Sc. Research Assistant

Faculty Profile:

Dr. Chandru.H
Senior Scientist/ Director

Dr. Chandru earned his undergraduate degree in Life Sciences from Yuvaraja’s College, Mysore, University of Mysore, and his postgraduate degree in Biochemistry from the Department of Studies in Biochemistry, Manasagangotri, University of Mysore, Karnataka state, India. He subsequently obtained a Ph.D. in Biochemistry from the University of Mysore, where his research focused on drug targeting to mammary adenocarcinoma cells (Ehrlich ascites tumor) as well as angiogenesis and metastasis in breast, cervical, and ovarian cancers. He conducted his postdoctoral research at Dartmouth Medical School in Hanover, New Hampshire, USA, under the supervision of Professor Radu Varghese Stan, where he explored the role of PV1 in cancer progression. Subsequently, he joined a prestigious research laboratory within the Department of Medicine at McMaster University in Hamilton, Ontario, Canada, worked with renowned professors Martin Kolb and Jack Gauldie. During his tenure at McMaster, he focused on angiogenesis in relation to pulmonary fibrosis, specifically examining the interplay between TGFβ1 and HIF1α in the advancement of this condition.  

Dr. Chandru has also served as a faculty member at several institutions, including the University of Mysore, Tumkur University, Rai University, and MGM University, where he taught Biochemistry, Biotechnology, and Stem Cell and Regenerative Medicine to postgraduate students. Furthermore, he has worked as a scientist in the Research and Development unit of a biomedical research laboratory within the pharmaceutical industry and as a biochemist on a project funded by a children’s hospital in Boston, USA, which aimed to develop a diabetes vaccine. His responsibilities involved conducting clinical trials at the Diabetes Care and Research Centre in Bangalore, India. 

His primary research areas include angiogenesis and metastasis in cancer, as well as pulmonary fibrosis, with a focus on growth factors, signaling pathways, and extracellular matrix biology related to these diseases. He utilizes animal models and in vitro cell culture techniques to investigate disease mechanisms and the efficacy of novel drugs in preclinical settings.  

Dr. Chandru has been involved with various academic committees, serving as a member of the Board of Studies and Board of Examinations in Biochemistry, Biotechnology, Molecular Biology, and Stem Cell Biology for postgraduate programs. He is a life member of several global scientific organizations, including the North American Vascular Biology Organization (NAVBO, USA), the European Respiratory Society (ERS, Switzerland), and the Indian Science Congress Association (ISCA, India). Additionally, he actively reviews research papers for international journals, including Phytotherapy Research, Exploration of Targeted Anti-Tumor Therapy, and the Journal of Cancer Therapy.  

Since June 2024, Dr. Chandru has been part of the faculty at BGS-Global Institute of Medical Sciences, serving as a Senior Scientist and Director at the BGSGIMS-Research Institute, where he is committed to research and development. He has published numerous research papers in high-impact international journals.  

Publications:  

  1. Chandru Hanumegowda, Muttanahally Eraiah Mohan. Hypoxia inducible factor-1α in pulmonary fibrosis: A promising therapeutic target. European Journal of Medical and Health Sciences.  2025; 7 (2): 27-31. 
  2. Chandru Hanumegowda, Krishnamurthy Narayanappa, Ravindra Kale, Muttanahally Eraiah Mohan. EMMPRIN plays a vital role in cancer metastasis by regulating MMPs and VEGF.  European Journal of Medical and Health Sciences. 2025; 7 (3): 32-38.    
  3. Chandru Hanumegowda, Kjetil Ask, Jack Gauldie, Martin Kolb. Interdependence of HIF1α and TGFβ1 activity in induction of pulmonary fibrosis. European Respiratory Journal. 2013; 42, 516.
  4. Chandru Hanumegowda, Laszlo Farkas, Martin Kolb. Angiogenesis in pulmonary fibrosis too much or not enough? CHEST. 2012; 142:200-207.  
  5. Chandrappa S, Chandru H, Sharada AC, Vinaya K, Karunakumar M, Rangappa KS. Synthesis and in vivo anti-cancer and anti-angiogenic effects of novel thioxothiazolidin-4-one derivatives against transplantable mouse tumor. Medicinal Chemistry Research. 2010; 19:236-249.
  6. Chandru H, Ananda Kumar CS, Sharada AC, Rangappa KS. Anti-angiogenic and growth inhibitory effects of synthetic novel 1, 5-diphenyl-1, 4 pentadiene-3-one-3-yl ethanone pyridine curcumin analogues on Ehrlich ascites tumor in vivo. Medicinal Chemistry Research. 2008; 17:515-529.
  7. Ananda Kumar CS, Chandru H, Sharada AC, Rangappa KS. Synthesis andevaluationof1-benzhydryl-sulfonyl piperazine derivatives as inhibitors of tumor growth and tumor angiogenesis of mouse Ehrlich ascites tumor in vivo. Medicinal Chemistry. 2008; 4: 466-472.
  8. Chandru H, Sharada AC, Manjunath S. Expression of Matrix Metalloproteinase (MMP2) and Extracellular Matrix Metalloproteinases Inducer (EMMPRIN) in Benign and Advanced Breast Cancer Tissue Samples. Biochemistry (Moscow) Biomedical Chemistry. 2007; 1: 347-351.  
  9. Chandru H, Sharada AC, Bettadaiah BK, Ananda Kumar CS, Rangappa KS, Sunila,  Jayashree K. In vivo growth inhibitory and anti-angiogenic effects of synthetic novel dienone cyclopropoxy curcumin analogs on mouse Ehrlich ascites tumor. Bioorganic &Medicinal Chemistry. 2007; 15:7696-7703. 
  10. Chandru H,Sharada AC. Screening of selected Indian medicinal plants for anti-angiogenesis activity. My Science. 2007; 2: 13-20.
  11. Chandru H, Sharada AC. Titrimetric and spectrophotometric methods for the assay of Astemizole in non-aqueous medium. Bulgarian Chemical Communication. 2007; 39: 48-57.
  12. Chandru H, Sharada AC. Simple and rapid methods for the analysis of Captropril in dosage forms. Journal of Chemistry. 2007; 4: 216-221.
  13. Chandru H, Sharada AC. Anti-angiogenic effects of synthetic analogs of curcumin. Journal of Biomedical Research. 2007; 10: 242-248.

Dr. Suman Samaddar
Research Scientist-II

Dr. Suman Samaddar completed his undergraduate degree in Pharmacy and later earned an M.Pharm in Pharmaceutical Biotechnology from Bharati Vidyapeeth Deemed University in Pune, Maharashtra, India. He subsequently attained his Ph.D. in Pharmaceutical Sciences from Jawaharlal Nehru Technological University in Andhra Pradesh, India. From 2005 to 2020, he held various academic and research positions, including Probationary Officer and Associate Professor. Since 2021, he has been working as a Research Scientist-II at the BGS GIMS Research Institute. His research primarily focuses on neuroprotection in diabetic peripheral neuropathy and neurodegenerative diseases. He investigates the implications of sphingolipid metabolic homeostasis disturbances in diabetic peripheral neuropathy, explores the beneficial effects of siRNA-based gene silencing on diabetic peripheral neuropathy and neurodegenerative disorders, and determines the role of genes linked to multi-drug resistance in dermatophytes through a transcriptomic approach.

Dr. Samaddar has designed and led research projects as the principal investigator, including an in-depth study on the pancreatic islet regeneration potential of a phytosaponin in Type I diabetes mellitus, funded by Rajiv Gandhi University of Health Sciences, Bangalore, from 2017 to 2020. He has also actively participated as a co-investigator in evaluating the neuroprotective effects of biologically active components (polyphenols) from marine algae in diabetic peripheral neuropathy, with funding from Rajiv Gandhi University of Health Sciences between 2015 and 2017.

His professional affiliations include:

  1. Research Co-supervisor (PhD) at KLE Academy of Higher Education (Deemed University), Belagavi, Karnataka, India (2023-Present).
  2. Research Co-supervisor (PhD) at Amity University, Chandigarh, India (2022-Present).
  3. Reviewer for the ‘International Journal of Biological Macromolecules’ and ‘Life Sciences’.

Dr. Suman Samaddar has published several research articles in peer-reviewed journals and contributed some chapters to reputable books on topics such as Marine Algae in Diabetes and Its Complications, Endoplasmic Reticulum Stress and Protein Misfolding in Neurodegenerative Diseases, Nanoparticle-based siRNA Delivery in the Treatment and Management of Alzheimer’s Disease, and the Efficacy of Natural Anti-Inflammatory Compounds in Neurological Disorders.

Publications:

  1. Moqbel AMR, Hariprasad MG, Suman S, Duaa AB, Sumaia AAAH, Sourav G, Apurwa D. siRNA targeting PARP-1 alleviates diabetic peripheral neuropathy in a streptozotocin-induced rat model. J Drug Target. 2025; 33 (3): 424-435.
  2. Samaddar S, Redhwan MAM, Eraiah MM, Koneri R. Neurotrophins in peripheral neuropathy: exploring pathophysiological mechanisms and emerging therapeutic opportunities. CNS Neurol Disord Drug Targets. 2025; 24(2): 91-101.  
  3. Moqbel A, Hariprasad MG, Samaddar S, Duaa AB, Ali A, Guha S. Chitosan/siRNA nano particles targeting PARP-1 attenuate Neuroinflammation and apoptosis in hyperglycemia-induced oxidative stress in Neuro2a cells. Int J Biol Macromol. 2024; 282:136964-136964.
  4.  Moqbel A, Hariprasad MG, Samaddar S, Sumaia AA, Yadav V, Mukherjee A, Kumar R. Small interference (RNAi) technique: Exploring its clinical applications, benefits and limitations. Eur J Clin Invest.2023; 00:e14039
  5. Redhwan MAM, Hariprasad MG, Samaddar S, Hard SAAA. SiRNA a promising tool for diabetes complications. Open Nano. 2023; 13 (100174):1-14.   
  6. Shantharaju SA, Samaddar S, Kumaraswamy B, Okade R, Koneri R, Joshua L. Clinico-microbiological study of dermatophytosis in a tertiary care center and emergence of multi-drug resistant dermatophyte Trichophyton tonsurans in the sub-population of West Bengaluru, Karnataka. IP Indian J Clin Exp Dermatol. 2023; 9(3):135-141.  
  7. Redhwan MA, Samaddar S, MG H, Hard SA, Deka G, Godfrey A. Evaluation of protective effects of polyphenols of the marine brown alga Ecklonia cava against potassium bromate induced nephrotoxicity in rats. Pharmacog Res. 2023; 15 (3): 544-550.  
  8. Moumita H, Dalia DM, Tamal M, Prakash BR, Suman S. Optimization and characterization of hepatoprotective andrographolide microspheres in the necrotic rat model. Journal of Drug Delivery Science and Technology. 2021; 65 (102679) :1-12.  
  9. Samaddar S, Koneri R. Polyphenols of marine red macro alga Symphyocladia latiuscula ameliorate diabetic peripheral neuropathy in experimental animals. Heliyon. 2019; 5(5) e01781:1-8.  
  10. Samaddar S, Koneri R. Neuroprotective efficacy of polyphenols of marine brown macro alga Ecklonia cava in diabetic peripheral neuropathy. Pharmacog Mag. 2019; 15(66): S468-75.  
  11. Samaddar S, Koneri R, Joseph VV, Deepak KJ. Triterpenoid saponin from Momordica tuberose(Cucurbitaceae) stimulates insulin secretion from isolated mouse pancreatic islets and provides protection from streptozotocin and high-glucose induced injury. Indian J Pharm Educ Res. 2019; 53 (2s): 23-32. 
  12. Suman Samaddar, Deepak K. Jha, Raju Koneri. Optimization of pancreatic islet isolation from rat and evaluation of islet protective potential of a saponin isolated from fruits of Momordica dioica. Journal of Applied Pharmaceutical Science. 2020; 10 (7): 89-99.
  13. Samaddar S, Koneri R. Saponin of Momordica cymbalaria exhibits anti-inflammatory activity by suppressing the expression of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 macrophages. Pharmacognosy Research. 2019; 11(1): 8-13.   

Ms. Lincy B. Joshua
Laboratory Manager  

Ms. Lincy B. Joshua is a clinical research professional with a strong academic foundation in Chemistry, Botany, and Biotechnology from St. Joseph’s University and Biomedical Genetics from Vellore Institute of Technology and is currently pursuing a Ph.D. in Clinical Research. Additionally, she has honors in Neuro-Linguistic program and Biotechniques. She brings over a decade of multidisciplinary experience, including cytogenetics, molecular diagnostics, and clinical trial coordination.  

She has completed her cytogenetics training at St. John’s Medical College and Hospital. From 2011to2016, she worked as a Cytogeneticist, playing an important role in establishing genetics testing lab and central research lab. 

Since 2016, she has been working as a Manager at BGSGIMS-Research Institute, coordinating over 40 clinical trials (Phases I–IV) across a wide range of therapeutic areas in collaboration with Leads Clinical Research and Bio Services Pvt. Ltd. Her expertise ensures that each study adheres to the highest standards of clinical and regulatory compliance.

In addition to her research roles, Ms. Joshua is actively engaged in academic teaching, training workshops, and mentorship both in Genetics and Clinical Research.

Her research work includes a KBITS-funded project focused on identifying mutations in genetically inherited anemia, as well as studies on cancer prevention screening and the prevalence of infections and diseases among lower socio-economic populations. She worked as part of a KBITS funded project on identifying mutations in genetically inherited anemia. Her other research projects include Preventive screening for cancers, Prevalence of certain infections and diseases in lower socio-economic groups. She has comprehensive exposure to clinical research regulations, laboratory quality standards, and advanced biomedical techniques. It includes Good Clinical Practice (GCP) certifications, requirements for NAAC and NABL. Additionally, she has received hands-on training in specialized laboratory techniques such as BD FACS analysis, semi-automated electrophoresis, and fluorescence in- situ hybridization (FISH).

Mr. Sanjay K
Research Assistant

Mr. Sanjay earned his undergraduate degree in life sciences in 2021 and subsequently obtained his master’s degree in Biochemistry from Padmashree Institute in Bangalore. Currently, he is employed as a research assistant, where he is involved in preparing laboratory reagents, maintaining instruments, and providing support for research activities.